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Sitges Meeting Discusses European Access to New Hepatitis C Drugs

Community activists, researchers, and regulatory and pharmaceutical representatives met this month in Sitges, Spain, to discuss early and expanded access to direct-acting antiviral agents for hepatitis C, especially for difficult-to-treat patients including those with HIV/HCV coinfection and cirrhosis. alt

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HCV Protease Inhibitor Danoprevir Promising in Early Trial

Experimental HCV protease inhibitor danoprevir (formerly RG7227 and ITMN-191) was safe and showed good antiviral activity at higher doses in a 14-day study of treatment-naive and previously treated genotype 1 chronic hepatitis C patients. alt

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Updated PegIntron Label Psychiatric Warning

Package information for Intron-A conventional interferon and PegIntron pegylated interferon were updated with a warning that people with psychiatric and substance use disorders may experience worse symptoms. alt

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PSI-7977 Trial Adds New Regimens

The ELECTRON trial, testing the HCV polymerase inhibitor PSI-7977, has added new arms looking at regimens with shorter duration or no interferon for people with HCV genotypes 1, 2, and 3.

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BI201335 Shows Potent Activity against HCV

HCV protease inhibitor BI201335 plus pegylated interferon/ribavirin was well-tolerated and demonstrated good activity in treatment-naive and -experienced genotype 1 chronic hepatitis C patients. alt

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