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Other Infections

Delamanid for Tuberculosis Approved in Europe, New Drugs Under Study

The European Union recently approved the new anti-tuberculosis drug delamanid (Deltyba) for use in combination therapy for people with multidrug-resistant TB. In related news, the Stop TB Partnership announced that it will make another new drug, bedaquiline (Sirturo), available in more than 100 low- and middle-income countries.

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DDW 2014 and EASL 2014: Rifaximin May Be Beneficial for People with Advanced Liver Cirrhosis

The antibiotic rifaximin may help prevent or improve hepatic encephalopathy and bleeding varices in people with decompensated liver disease, according to studies presented at the recent EASL International Liver Congress and Digestive Disease Week.

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EASL 2014: Fatty Liver Disease Is a Risk Factor for Heart Disease and Diabetes

Non-alcoholic fatty liver disease is associated with increased risk of cardiovascular disease, as indicated by atherosclerosis of the carotid artery, according to a study presented at the 49thEASL International Liver Congress (EASL 2014) this week in London. A related study found that fatty liver is also associated with diabetes, and reduction of liver fat lowers diabetes risk.

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Coalition Calls for Wider Use of Sexual Health Care Services in U.S.

The National Coalition for Sexual Health -- comprised of nearly 40 organizations focused on HIV, sexually transmitted diseases, and other aspects of sexual health -- last week issued a call-to-action and announced new resources aimed at improving access to and acceptance of sexual health services, which are now more readily available under the Affordable Care Act (ACA).

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March 24 Is World TB Day

Monday, March 24, is World TB Day, an opportunity to raise awareness about tuberculosis and the need for expanded testing and treatment worldwide. TB remains a threat in high-income countries including the U.S. as well as in resource-limited settings, and it is a major cause of death among people with HIV. The Stop TB Partnership estimates that 9 million people worldwide get sick with TB annually, but 3 million of them do not get the care they need.

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FDA Approves HPV DNA Test as Pap Smear Alternative for Cervical Cancer Screening

The U.S. Food and Drug Administration (FDA) last week approved Roche Diagnostics' cobas human papillomavirus (HPV DNA test for initial screening for cervical cancer. The test detects high-risk or cancer-causing HPV types including HPV-16 and HPV-18. Women who test positive for high-risk HPV can then undergo further testing for pre-cancerous or malignant cell changes.

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CROI 2014: New Drugs, Novel Combos Top Tuberculosis News at Conference

Replacing 2 drugs in standard tuberculosis (TB) regimens may shorten therapy and experimental drugs look good in early studies, but a promising diagnostic test did not lead to improvements in mortality, researchers reported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this month in Boston.

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EASL 2014: Obeticholic Acid Looks Promising for Primary Biliary Cirrhosis, May Improve Gut Health

Obeticholic acid (OCA) leads to biochemical improvement for patients with primary biliary cirrhosis, according to the first Phase 3 trial for this population in 2 decades, researchers reported at the 49th EASL International Liver Congress (EASL 2014) last week in London. A related study found that OCA help may reduce intestinal inflammation and bacterial leakage.

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CROI 2014: Natural History of HIV-Related Anal Dysplasia [VIDEO]

The progression of anal dysplasia is highly variable in people with HIV, progressing in some and remaining stable or regressing in others, according to a retrospective analysis of nearly 3000 participants presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) last week in Boston. Progression to invasive anal cancer, however, was uncommon.

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