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AASLD 2017: Mavyret Shows High Cure Rates for HCV Genotype 3 and Cirrhosis

Glecaprevir and pibrentasvir, the 2 drugs in the recently approved Mavyret coformulation, demonstrated high sustained response rates for chronic hepatitis C patients with HCV genotype 3 and for people with liver cirrhosis, according to a pair of reports presented at the 2017 AASLD Liver Meeting last week in Washington, DC.

An integrated analysis of clinical trial data showed that glecaprevir/pibrentasvir taken for 8 weeks cured 98% of non-cirrhotic people with hard-to-treat genotype 3, while a 12-week course cured 100% of genotype 3 patients with cirrhosis. A related analysis showed that the combination taken for 12 or 16 weeks cured 96% of patients with compensated cirrhosis across all genotypes.

Direct-acting antivirals used in interferon-free regimens can now cure most people with chronic hepatitis C virus, including patients who were previously considered difficult-to-treat, such as those with genotype 3, advanced liver or kidney disease, or HIV/HCV coinfection.

AbbVie's Mavyret (marketed as Maviret in Europe), which was approved by the Food and Drug Administration in August, contains the HCV NS3/4A protease inhibitor glecaprevir and the NS5A inhibitor pibrentasvir. Both drugs are pangenotypic, meaning they are active against all HCV genotypes.

Genotype 3

Steven Flamm of Northwestern Feinberg School of Medicine in Chicago and colleagues performed an integrated analysis of efficacy and safety data from Phase 2 and 3 clinical trials of glecaprevir/pibrentasvir for previously untreated people with HCV genotype 3, either without cirrhosis or with compensated cirrhosis.

The analysis included 7 studiesin the ENDURANCE, EXPEDITION, SURVEYOR, and MAGELLAN programs,with a total of 571 participants. About 60% were men, around 90% were white, and the mean age was approximately 48 years for non-cirrhotic patients and 56 years for those with cirrhosis. Almost all (99%) had HCV subtype 3a.

Among the non-cirrhotic patients, about 15% had advanced (stage F3) fibrosis. Some of the trials included people with HIV, advanced kidney disease (EXPEDITION-4) and transplant recipients. Two-thirds of participants had a history of injection drug use, 17% were on opioid substitution therapy, and recent illicit drug use was not excluded. About a quarter had NS5A resistance-associated variations at baseline.

Of the patients without cirrhosis, 208 received once-daily glecaprevir/pibrentasvirfor 8 weeks and 294 were treated for 12 weeks. All of the 69 people with cirrhosis received the 12-week course. None of the participants used ribavirin. The endpoint was sustained virological response, or undetectable HCV RNA at 12 weeks post-treatment (SVR12).

In the pooled analysis, 95% of participants without cirrhosis who were treated for 8 weeks and the same proportion of those treated for 12 weeks achieved SVR12. After excluding people with non-virological treatment failure in a modified analysis, cure rates rose to 98% and 99%, respectively. There were 5 relapses in the 8-week group and 4 in the 12-week group. The researchers concluded that for non-cirrhotic patients, there was no additional benefit of extending treatment from 8 to 12 weeks.

Among cirrhotic patients treated for 12 weeks the SVR12 rate was 97%, rising to 100% after excluding non-virological treatment failures. There were no relapses.

People with stage F3 fibrosis had a slightly, but not significantly, lower response rate using 8 compared with 12 weeks of therapy (94% vs 100%), a difference not seen among those with absent to moderate (stage F0-F2) fibrosis.

Response rates did not differ significantly based on pre-treatment HCV viral load, use of opioid substitution therapy, or recent illicit drug use. All African-American patients were cured (a group that did not respond as well to interferon-based therapy).

Glecaprevir/pibrentasvirwas generally safe and well-tolerated, with no drug-related serious adverse events and 3 treatment discontinuations due to adverse events. The most common events reported by at least 10% of patients were headache (19%-24%), fatigue (10%-19%), and nausea (10%-13%).

These findings, Flamm said, support recent changes to AASLD-IDSA HCV treatment guidelinesadding Mavyret as a recommended regimen for first-line treatment of people with HCV genotype 3, without the need for baseline resistance testing or addition of ribavirin. Despite the slightly lower response rate for people with advanced fibrosis, he said he is confident that an 8-week regimen is adequate for these patients.

Compensated Cirrhosis

Edward Gane of Auckland City Hospital in New Zealand presented results from a similar analysis of clinical trials that included treatment-naive or previously treated people with compensated cirrhosis across HCV genotypes 1-6.

This analysis included 4 studies with a total of 308 participants. About 65% were men, most were white, and the mean age was 59 years. Most had genotypes 1 (40%), 2 (12%), 3 (38%), or 4 (7%), with just 9 people having genotypes 5 or 6. People with HIV or hepatitis B coinfection were excluded.

Participants had cirrhosis according to liver biopsies, Fibroscan imaging, or the FibroTest biomarker index, but they had no history of liver decompensation. Most had a baseline Child-Pugh score of 5 (Class A). A small number (6%) had advanced chronic kidney disease.

A majority of participants (59%) were being treated for the first time, while the rest had been unsuccessfully treated with interferon-based therapy, sofosbuvir (Sovaldi) plus ribavirin, or HCV protease inhibitors or NS5A inhibitors.

Most study participants (245) were treated with glecaprevir/pibrentasvir for 12 weeks, with the remaining 63 receiving a 16-week course. The different treatment durations were used in different studies and they were not compared head-to-head. Again, no one received ribavirin.

In the pooled analysis, the overall SVR12 rate was 96%, rising to 97% in a modified analysis that excluded people with non-virological treatment failure. There were 5 viral breakthroughs during treatment and 3 post-treatment relapses. By genotype, SVR12 rates were 94% for genotype 1, 97% for genotype 3, and 100% for genotypes 2, 4, 5, and 6.

Again, treatment was safe and well-tolerated, with no drug-related serious adverse events and 2 events leading to treatment discontinuation. Here too, the most common adverse events were fatigue (19%), headache (16%), and nausea (10%). There was no increase in the frequency or severity of side effects compared with those seen in non-cirrhotics, even though glecaprevir levels were about twice as high in people with cirrhosis, Gane said.

"This integrated analysis supports the high efficacy and favorable safety profile of glecaprevir/pibrentasvirin patients with HCV genotypes 1-6 infection and compensated cirrhosis," the researchers concluded.

10/31/17

Sources

S Flamm et al. Efficacy and safety of glecaprevir/pibrentasvir for 8 or 12 weeks in treatment-naive patients with chronic HCV genotype 3: an integrated phase 2/3 analysis. The Liver Meeting. Washington, DC, October 20-24, 2017. Abstract 62.

E Gane et al. Efficacy, safety, and pharmacokinetics of glecaprevir/pibrentasvir in adults with chronic genotype 1-6 hepatitis C virus infection and compensated cirrhosis: an integrated analysis. The Liver Meeting. Washington, DC, October 20-24, 2017. Abstract 74.